The Protective Effect of Ethanolic Extract of Unripe Pulp of Carica papaya (Pawpaw) Against Potassium Bromate Induced Tissue Damage in Wistar Rats

摘要

The protective role of ethanolic extract of unripe pulp of Carica papaya (fruit), against potassiumbromate induced tissue damage in wistar rats was investigated. The animals were grouped into four groups (A, B, C, D) of five rats. Group A was administered 1 mL of 0.25 M sucrose solution. 60 mg/kg of Potassium bromate KBrO₃ was administered orally to rats in groups B, C and D. Groups C and D were pretreated with 250 and 500 mg/kg of the extracts for fourteen (14) days, respectively. The organ to body-weight ratio, total amino acid, total protein and malondialdeyde (MDA) concentration in the brain, spleen, kidney, liver, and heart were colorimetrically measured as an assessment of the level of tissue damage. All the parameters studied increases significantly in all the tissues of rats group B. There was significant decrease in the organ-to-body weight ratio and total protein level in all the tissues investigated (pCarica papaya may be protective against KBrO₃ induced tissue damage in Wistar rats.