The role of nutrition in promoting growth in pre-term infants with bronchopulmonary dysplasia: a prospective non-randomised interventional cohort study

摘要

Background Pre-term infants who develop bronchopulmonary dysplasia (BPD) are at risk of postnatal growth failure. It has been reported that energy expenditure is higher in infants with BPD than in those without BPD. The aim of the study was to evaluate whether increasing the enteral energy intake of pre-term infants with BPD can improve post-natal growth. Methods This prospective, non-randomised interventional cohort study was designed to assess growth in 57 preterm infants with BPD (gestational age t test or the Mann-Whitney test; the discrete variables were compared using the chi-squared test. Linear regression analysis was used to investigate the independent contribution of enteral energy intake to weight gain velocity. Results The duration of parenteral nutrition was similar in the historical and intervention groups (43.7?±?30.9 vs 39.6?±?17.4?days). After the withdrawal of parenteral nutrition, enteral energy intake was higher in the infants in the intervention group with mild or moderate BPD (131?±?6.3 vs 111?±?4.6?kcal/kg/day; p?vs 105?±?5.1?kcal/kg/day; p?vs 3.1?±?0.23?g/kg/day). Weight gain velocity was greater in the infants in the intervention group with mild or moderate BPD (14.7?±?1.38 vs 11.5?±?2?g/kg/day, p? Conclusions On the basis of the above findings, it seems that improved nutritional management promotes post-natal ponderal growth in pre-term infants with BPD.