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首页> 外文期刊>BMC Neurology >Clinical, lifestyle, socioeconomic determinants and rate of asymptomatic intracranial atherosclerosis in stroke free Pakistanis
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Clinical, lifestyle, socioeconomic determinants and rate of asymptomatic intracranial atherosclerosis in stroke free Pakistanis

机译:无卒中巴基斯坦人的临床,生活方式,社会经济决定因素和无症状颅内动脉粥样硬化发生率

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Background Intracranial Atherosclerotic Disease (ICAD) is the most frequent etiology of stroke with high prevalence among Asians. Despite this, early determinants of ICAD have not been described from this region. Methods The study is an analytical prospective cross-sectional study of 200 adults from Radiology Departments of two diagnostic centers in Karachi. Eligible participants confirmed the absence of stroke symptoms via the Questionnaire for Verifying Stroke Free Status (QVSFS) and underwent an interview covering medical, socio demographic, lifestyle and anthropometric evaluation using locally validated and standardized definitions. Magnetic Resonance Images (MRI) were centrally reviewed to detect ICAD using the criterion used in the Warfarin–Aspirin Symptomatic Intracranial Disease study. The risk factors associated with asymptomatic ICAD are reported along with prevalence ratios. Results Of the 200 participants, ICAD was found in 34.5% (n?=?69) of the participants. Mean age was 37.1 (S.D 15.1) years with 62% younger than 45?years. Self-reported hypertension was found in 26.5% subjects, diabetes in 9%, dyslipidemia in 5% and depression in 60%. Smokeless tobacco (Adjusted PR 3.27 (1.07-6.05)), Western diet, high socioeconomic status (Adjusted PR 2.26 (1.99-5.62)) and dyslipidemia (Adjusted PR 1.88 (1.25-2.21)) had significant associations with ICAD after multivariable analysis. Age, gender, diabetes, hypertension, depression and physical activity did not have a significant association. Conclusion ICAD was found on MRI in one in three asymptomatic Pakistanis and was associated with modifiable risks. Initiatives targeting primary prevention may be able to decrease the burden of disease caused by stroke due to ICAD. Study Registration Number NCT02072876 2/25/2014
机译:背景颅内动脉粥样硬化病(ICAD)是亚洲人中最常见的卒中病因,发病率很高。尽管如此,该地区尚未描述ICAD的早期决定因素。方法本研究是对来自卡拉奇两个诊断中心放射科的200名成人进行的分析性前瞻性横断面研究。符合条件的参与者通过“无卒中状态验证问卷”(QVSFS)确认没有中风症状,并接受了就诊,访谈,医疗,社会人口统计学,生活方式和人体测量学评估,均使用了经过本地验证和标准化的定义。使用华法林-阿司匹林症状性颅内疾病研究中使用的标准,对磁共振图像(MRI)进行了中央检查,以检测ICAD。报告了与无症状ICAD相关的危险因素以及患病率。结果200名参与者中,有34.5%(n?=?69)的参与者发现了ICAD。平均年龄为37.1(S.D 15.1)岁,比45岁的年轻人低62%。自我报告的高血压患者占26.5%,糖尿病患者占9%,血脂异常患者占5%,抑郁症患者占60%。经过多变量分析后,无烟烟草(调整后的PR 3.27(1.07-6.05)),西方饮食,较高的社会经济地位(调整后的PR 2.26(1.99-5.62))和血脂异常(调整后的PR 1.88(1.25-2.21))与ICAD有显着相关性。年龄,性别,糖尿病,高血压,抑郁和体育锻炼没有显着相关性。结论在三分之一无症状的巴基斯坦人中,MRI上发现了ICAD,并伴有可改变的风险。针对一级预防的倡议可能能够减轻由ICAD引起的中风引起的疾病负担。研究注册号NCT02072876 2/25/2014

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