Current Atherosclerosis of Intracranial and Extracranial Vessels in Ischemic Stroke Patients.

摘要

Racial differences in the distribution of cerebrovascular occlusive disease are well documented. Extracranial stenosis is more common in Caucasian while intracranial stenosis is more common in Asian, Hispanic and African-American. The prevalence of asymptomatic intracranial stenosis in middle age and elderly general population in China was about 7%. The frequency of intracranial atherosclerosis among patients with stroke and TIA is 40 to 50% in Chinese populations. Concurrent extracranial and intracranial stenoses is common in Asian, the incidence range from 10 to 39% in patients with stroke. The current population of China is 1.3 billion and it was estimated that 30% of the population will be aged 60 and above by 2050 in China. The incidence of stroke in China is 215 per 100000 which is one of the highest among the world and this burden is expected to escalate in the coming decades. However, studies of concurrent stenoses among Chinese are scarce. The aim of this precis is to present my studies that were conducted mainly among Chinese stroke patients on this particular field. The scope of the studies covers the following 4 areas: (1) Identification of Long-term prognosis of patients with concurrent stenoses; (2) Long-term prognosis of patients with concurrent stenoses and ischemic heart disease; (3) Lesion pattern and stroke mechanisms in concurrent stenoses; and (4) genetic polymorphisms of ischemic stroke patients with concurrent stenoses. The background, objectives, subjects, methods, results, and conclusions of these studies will be presented in this precis.