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首页> 外文期刊>BMC Bioinformatics >Texture based skin lesion abruptness quantification to detect malignancy
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Texture based skin lesion abruptness quantification to detect malignancy

机译:基于纹理的皮肤病变突变定量检测恶性肿瘤

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摘要

Abruptness of pigment patterns at the periphery of a skin lesion is one of the most important dermoscopic features for detection of malignancy. In current clinical setting, abrupt cutoff of a skin lesion determined by an examination of a dermatologist. This process is subjective, nonquantitative, and error-prone. We present an improved computational model to quantitatively measure abruptness of a skin lesion over our previous method. To achieve this, we quantitatively analyze the texture features of a region within the lesion boundary. This region is bounded by an interior border line of the lesion boundary which is determined using level set propagation (LSP) method. This method provides a fast border contraction without a need for extensive boolean operations. Then, we build feature vectors of homogeneity, standard deviation of pixel values, and mean of the pixel values of the region between the contracted border and the original border. These vectors are then classified using neural networks (NN) and SVM classifiers. As lower homogeneity indicates sharp cutoffs, suggesting melanoma, we carried out our experiments on two dermoscopy image datasets, which consist of 800 benign and 200 malignant melanoma cases. LSP method helped produce better results than Kaya et al., 2016 study. By using texture homogeneity at the periphery of a lesion border determined by LSP, as a classification results, we obtained 87% f1-score and 78% specificity; that we obtained better results than in the previous study. We also compared the performances of two different NN classifiers and support vector machine classifier. The best results obtained using combination of RGB color spaces with the fully-connected multi-hidden layer NN. Computational results also show that skin lesion abrupt cutoff is a reliable indicator of malignancy. Results show that computational model of texture homogeneity along the periphery of skin lesion borders based on LSP is an effective way of quantitatively measuring abrupt cutoff of a lesion.
机译:皮肤病灶周围的色素图案突变是检测恶性肿瘤最重要的皮肤镜特征之一。在当前的临床环境中,皮肤病的突然切除是由皮肤科医生检查确定的。此过程是主观的,非定量的并且容易出错。我们提出了一种改进的计算模型,以定量地评估我们先前方法中皮肤病变的突然性。为此,我们定量分析了病变边界内区域的纹理特征。该区域由病变边界的内部边界线界定,该边界边界线是使用水平集传播(LSP)方法确定的。此方法无需大量的布尔运算即可提供快速的边界收缩。然后,我们建立均一性,像素值的标准偏差以及收缩边界和原始边界之间区域的像素值平均值的特征向量。然后使用神经网络(NN)和SVM分类器对这些向量进行分类。由于较低的同质性表明存在尖锐的临界值,提示黑色素瘤,我们在两个皮肤镜图像数据集上进行了实验,其中包括800例良性和200例恶性黑色素瘤病例。 LSP方法比Kaya等人(2016)的研究产生了更好的结果。通过使用由LSP确定的病变边界周围的纹理均匀性,作为分类结果,我们获得了87%的f1得分和78%的特异性;与以前的研究相比,我们获得了更好的结果。我们还比较了两种不同的NN分类器和支持向量机分类器的性能。将RGB颜色空间与完全连接的多隐藏层NN结合使用可获得最佳结果。计算结果还表明,皮肤病灶的突然切除是恶性肿瘤的可靠指标。结果表明,基于LSP的沿皮肤病灶边界周围纹理均匀性的计算模型是定量测量病灶突变的有效方法。

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