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首页> 外文期刊>BMC Anesthesiology >Role of ultrasound guided transversus abdominis plane block as a component of multimodal analgesic regimen for lower segment caesarean section: a randomized double blind clinical study
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Role of ultrasound guided transversus abdominis plane block as a component of multimodal analgesic regimen for lower segment caesarean section: a randomized double blind clinical study

机译:超声引导下腹部横断平面阻滞作为下肢剖宫产多式镇痛方案的一种成分:一项随机双盲临床研究

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While opioids are the mainstay for post-operative analgesia after lower segment caesarean section, they are associated with various untoward effects. Ultrasound guided transversus abdominis plane (TAP) block has been postulated to provide effective analgesia for caesarean section. We evaluated the analgesic efficacy of this block for post caesarean analgesia in a randomised controlled trial. One hundred thirty-nine mothers undergoing caesarean delivery were randomised to receive TAP block with either 20?ml 0.375% ropivacaine or 20?ml saline after obtaining informed consent. All the subjects received a standard spinal anaesthetic and diclofenac was administered for post-operative pain. Breakthrough pain was treated with tramadol. Post-operatively, all the subjects were assessed at 0, 2, 4, 6, 8, 10, 12, 18 & 24?h. The primary outcome was the time to first analgesic request. The secondary measures of outcome were pain, nausea, sedation, number of doses of tramadol administered and satisfaction with the pain management. The median (interquartile range) time to first analgesic request was prolonged in the TAP group compared to the control group (p?
机译:虽然阿片类药物是下段剖宫产术后术后镇痛的主要手段,但它们与各种不良反应有关。超声引导的横贯腹平面(TAP)块已被假定为剖腹产提供有效的镇痛作用。我们在一项随机对照试验中评估了该阻滞剂对剖宫产后镇痛的镇痛效果。在获得知情同意后,将一百三十九名接受剖腹产的母亲随机接受20毫升0.375%罗哌卡因或20毫升生理盐水的TAP阻断治疗。所有受试者均接受标准的脊髓麻醉,并给予双氯芬酸治疗术后疼痛。突破性疼痛用曲马多治疗。术后,在0、2、4、6、8、10、12、18和24小时对所有受试者进行评估。主要结果是首次使用止痛药的时间。结局的次要指标是疼痛,恶心,镇静,曲马多的给药剂量和对疼痛的满意程度。与对照组相比,TAP组中首次止痛要求的中位时间(四分位间距)延长(p 0.0001)。 11?h(8,12)和4?h(2.5,6)。 TAP组服用曲马多的剂量中位数(四分位数范围)为0(0.1),而对照组为2(1,2)(p 0.0001)。在研究的所有方面,研究组的静止和运动疼痛评分均较低(p <0.0001)。研究组的产妇对缓解疼痛的满意度也更高(p = 0.0002)。 TAP组中的一名受试者在注射局部麻醉剂后出现惊厥。保守治疗后给予支持治疗,随后康复。 TAP阻滞剂用于多模式镇痛以减轻剖腹产后的疼痛时,可减轻疼痛,延长镇痛时间并减少补充类阿片的消耗。但是,使用该阻滞剂尚无局麻药全身毒性的风险。因此,需要确定更大的安全性试验和限制这种并发症的措施。该试验于2017年23月3日在印度临床试验注册中心(CTRI / 2017/03/008194)进行了注册(回顾性注册)。

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