Combined use of dexmedetomidine and propofol in monitored anesthesia care: a randomized controlled study

摘要

Backgroud Although propofol and dexmedetomidine have been widely used for monitored anesthesia care, their adverse effects necessitate the search for better methods. Therefore, we performed this randomized controlled trial to evaluate the combined use of propofol and dexmedetomidine. Methods Eighty-seven adult patients undergoing hand surgery under brachial plexus block were randomly allocated to receive 1.6?μg/ml of the target effect site concentration of propofol (P group) and infusion of 0.4?μg/kg/h dexmedetomidine following a loading dose of 1.0?μg/kg for 10?min (D group). The M group received a half-dose of both drugs simultaneously. The maintenance dose was adjusted to maintain an Observer Assessment of Alertness/Sedation score of 3. Cardiorespiratory variables, adverse effects, and drug efficacy were observed. Results The significantly higher mean arterial pressure (mmHg) in the D group [P group 86.9 (12.6), D group 96.0 (12.2), M group 85.6 (10.6), p =?0.004)] and a significantly higher heart rate (beat/min) in the P group were observed [P group 67.3 (9.0), D group 57.8 (6.9), M group 59.2 (7.4), p Conclusions The combined use of propofol and dexmedetomidine provided cardiovascular stability with decreased adverse effects. Additionally, it led to a similar onset time of propofol and achieved higher satisfaction scores. Trial registration KCT0001284 . Retrospectively registered 25 November 2014.