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首页> 外文期刊>BMC Gastroenterology >Three-dimensional whole-liver perfusion magnetic resonance imaging in patients with hepatocellular carcinomas and colorectal hepatic metastases
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Three-dimensional whole-liver perfusion magnetic resonance imaging in patients with hepatocellular carcinomas and colorectal hepatic metastases

机译:肝细胞癌和大肠肝转移患者的三维全肝灌注磁共振成像

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Background Three-dimensional (3D) whole-liver perfusion magnetic resonance(MR) imaging with parallel imaging, a novel imaging method to characterize tumor vascularization in vivo, has recently been applied to comprehensively image perfusion changes in large tumors. Coupled with new perfusion software, this technique enables motion correction, registration, and evaluation of perfusion MR parameters. The purpose of this study was to assess the feasibility of 3D whole-liver perfusion MR, for imaging hepatocellular carcinoma (HCC) and colorectal hepatic metastases (CRHM). Methods 26 patients with hepatic tumors (10 HCC; 16 CRHM) were subjected to 3D whole-liver perfusion MR with a temporal resolution of 3.7?seconds. The following estimated perfusion parameters were measured: the volume transfer constant Ktrans (min-1); the volume (Ve) of extravascular extracellular space (EES) per volume unit of tissue; and the flux rate constant between EES and plasma Kep (min-1). Statistical analysis was conducted to investigate inter-observer characteristics and significance of the measured parameters. Results Inter-observer agreement analysis (95% limits of agreement) yielded a mean difference of ?0.0048?min-1 (?0.0598?~?0.0502) for Ktrans , -0.0630?ml (?0.5405?~?0.4145) for Ve, and ?0.0031?min-1 (?0.0771?~?0.0709) for Kep respectively. When comparing images from patients with HCC vs. CRHM, significant differences were seen for the mean Ktrans (p?=?0.017), but not for Ve(p?=?0.117) or Kep(p?=?0.595). Conclusion Herein we show that 3D whole-liver MR perfusion imaging with semi-automatic data analysis is feasible and enables the reliable quantitative evaluation of the perfusion parameters for HCCs and CRHMs.
机译:背景技术并行成像的三维(3D)全肝灌注磁共振(MR)成像是一种表征体内肿瘤血管形成的新颖成像方法,最近已被广泛用于对大肿瘤的灌注变化进行成像。结合新的灌注软件,该技术可进行运动校正,配准和评估灌注MR参数。这项研究的目的是评估3D全肝灌注MR成像肝细胞癌(HCC)和大肠肝转移(CRHM)的可行性。方法对26例肝肿瘤(10例HCC; 16例CRHM)患者进行3D全肝灌注MR,时间分辨率为3.7秒。测量以下估计的灌注参数:体积转移常数K trans (min -1 );每体积单位组织的血管外细胞外空间(EES)的体积(V e );和EES与血浆K ep 之间的通量速率常数(min -1 )。进行统计分析以调查观察者之间的特征和所测量参数的重要性。结果观察者间的共识分析(一致同意的95%)得出K trans 的均值差异为0.0048?min -1 (?0.0598?〜?0.0502), V e 为-0.0630?ml(?0.5405?〜?0.4145),K 为-0.0031?min -1 (?0.0771?〜?0.0709) ep 。比较HCC和CRHM患者的图像时,平均K trans (p?=?0.017)有显着差异,而V e (p? =?0.117)或K ep (p?=?0.595)。结论本文证明了半自动数据分析的3D全肝MR灌注成像是可行的,并能够对HCC和CRHM的灌注参数进行可靠的定量评估。

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