Alterations in lung gene expression in streptozotocin-induced diabetic rats

摘要

Background Diabetes profoundly affects gene expression in organs such as heart, skeletal muscle, kidney and liver, with areas of perturbation including carbohydrate and lipid metabolism, oxidative stress, and protein ubiquitination. Type 1 diabetes impairs lung function, but whether gene expression alterations in the lung parallel those of other tissue types is largely unexplored. Methods Lung from a rat model of diabetes mellitus induced by streptozotocin was subjected to gene expression microarray analysis. Results Glucose levels were 67 and 260?mg/dl (p? Conclusions Gene expression in the lung is affected by type 1 diabetes in several specific areas, including apoptosis. However, the lung is resistant to changes in gene expression related to lipid and carbohydrate metabolism and oxidative stress that occur in other tissue types such as heart, skeletal muscle and kidney.