ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma

摘要

Inhaled ?22 adrenergic receptor (?22-AR) agonists are the mainstay of asthma therapy. The ?22-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Childrena??s Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46AG (Arg16Gly, rs1042713) and +79CG (Gln27Glu, rs 1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +46G was found to be associated with a better response to inhaled salbutamol (p 0.05) and with mild form of asthma (p 0.05). Polymorphism ADRB2 +46AG may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79CG polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.