Plasma Zinc Disposition in Subjects with Low Zinc Levels Following Administration of Polaprezinc (Zinc L-Carnosine Complex)

摘要

1.The plasma zinc disposition following administration of polaprezinc (Zinc L-Carnosine Complex) in six male subjects with an initial low serum zinc levels (<70 μg/dL) were compared to those in nineteen subjects with normal zinc levels.2.The plasma zinc concentration reached a maximum plasma concentration (Cmax; 191 ± 30 μg/dL) at 1.83 h and returned to baseline level at 6 h after administration of 75 mg of polaprezinc (containing 17 mg of zinc). The plasma zinc concentration decreased at a half-life of 3.44 h. The area under the curve for plasma concentrations over time (0-12 h after administration; AUC_(0-12)) was 1275 ± 138 μg?h~(-1)?dL~(-1).3.The plasma zinc level returned to the initial values at 6 h. It then decreased to values lower than those at baseline at 8 and 12 h following administration of polaprezinc.4.In comparison with data from subjects with a normal zinc level, the absorption of zinc in subjects with low serum zinc following administration of polaprezinc was relatively low, and the deviation of AUC_(0-12) was minimal.