Production method of protective L-carnosine derivative, L-carnosine, and crystalline L-carnosine zinc complex

摘要

It is an object of the present invention to provide a method for easily preparing a protective L-carnosine derivative and the like. In the method for producing the protective L-carnosine derivative of the present invention, by reacting the acid anhydride represented by formula (1) with the L-histidine derivative represented by formula (2), the protective L-carnosine represented by formula (3) It is characterized by including the process of producing a derivative (In the formula, R ¹ is a predetermined protective amino group, R ² is a predetermined protective amino group or a branching group, and R ⁷ and R ⁸ are hydrogen atoms. , Or an amino group protecting group, and R ⁹ is a hydrogen atom or a protecting group of a carboxy group}.