Gene therapy for Multiple Myeloma

摘要

Prognosis of multiple myeloma (MM) remains insufficient despite the intervention of high dose chemotherapynwith auto- or allo- hematopoietic stem cell transplantation and the advent of molecular target drugs such as thalidomide,nlenalidomide, and bortezomib. Further development or new concepts of therapeutic approaches are still required for MMntreatment. Current standard protocol for MM treatment does not include gene delivery method or oncolytic virus approaches.nSince MM is a disorder originated from B cell lineage, it involves immunological aspects in both pathogenesisnand clinical manifestations. Therefore, the comprehension of immunology as well as oncology is essential to exploit newntherapeutic approaches. Recently, novel therapeutic concepts for MM have been emerging. In this review, we present currentnprogress of gene therapy related to MM treatments as well as the overview of MM treatment history.