Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4

Yoshihiro Akimoto; Yuri Miura; Tosifusa Toda; Margreet A Wolfert; Lance Wells; Geert-Jan Boons; Gerald W Hart; Tamao Endo; Hayato Kawakami

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Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4

机译：糖尿病肾脏的形态学改变与包括α-肌动蛋白4在内的细胞骨架蛋白的O-GlcNAcycy增加有关

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The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) rats, and to discuss the relation between O-GlcNAcylation and the pathological condition in diabetes.

机译：本研究的目的是鉴定糖尿病模型五崎崎（GK）大鼠肾脏中O-连接的N-乙酰氨基葡萄糖（O-GlcNAcylation）修饰程度变化的蛋白质，并讨论它们之间的关系。 O-GlcNAcylation和糖尿病的病理状况。

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来源
《Clinical Proteomics》 |2011年第1期|p.1-16|共16页
作者
Yoshihiro Akimoto; Yuri Miura; Tosifusa Toda; Margreet A Wolfert; Lance Wells; Geert-Jan Boons; Gerald W Hart; Tamao Endo; Hayato Kawakami;
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作者单位

Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan;

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0015, Japan;

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0015, Japan;

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA;

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA;

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA;

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA;

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0015, Japan;

Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan;

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正文语种 eng
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关键词
O-GlcNAc modification; Hexosamine biosynthetic pathway; Kidney; Glomerulus; Cytoskeleton; α-actinin; GK Rat; Mass spectrometry; Proximity Ligation Assay;

机译：O-GlcNAc修饰;己糖胺生物合成途径;肾脏;肾小球;细胞骨架;α-肌动蛋白;GK大鼠;质谱;邻近结扎法;

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专利

1. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4 [J] . Clinical proteomics. . 2011,第1期

机译：糖尿病肾脏的形态变化与包括α-肌动蛋白4在内的细胞骨架蛋白的O-GlcNAcycy增加有关
2. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4 [J] . Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, Clinical proteomics. . 2011,第1期

机译：糖尿病肾脏的形态变化与包括α-肌动蛋白4在内的细胞骨架蛋白的O-GlcNAcycy增加有关
3. α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein [J] . June Yao, Tu Cam Le, Claudine H Kos, PLoS Biology . 2004,第6期

机译：α-肌醇蛋白-4介导的FSGS：由聚集和快速降解的细胞骨骼蛋白引起的遗传肾病
4. Discovery and Localization of Modified Lipids in Kidneys of Diabetic Mouse Model using Mass Difference Scanning and Imaging Mass Spectrometry [C] . Kerri J. Grove, Raf Van de Plas, Jeffery M. Spraggins, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：用大规模差分扫描和成像质谱法发现糖尿病小鼠模型肾脏改良脂质的发现与定位
5. BIOCHEMICAL AND MORPHOLOGICAL ANALYSIS OF CYTOSKELETAL PROTEINS AND TRAIL SECRETION DURING GLIDING MOTILITY IN THE MARINE BENTHIC DIATOM, AMPHORA COFFEAEFORMIS. [D] . WEBSTER, DANIEL ROBB. 1984

机译：海洋底栖动物两栖动物滑行运动过程中细胞骨架蛋白的生物化学和形态分析及轨迹分泌。
6. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4 [O] . Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, 2011

机译：糖尿病肾脏的形态学改变与包括α-肌动蛋白4在内的细胞骨架蛋白的O-GlcNAcycy增加有关
7. Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4 [O] . Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, 2011

机译：糖尿病肾脏的形态学改变与包括α-肌动蛋白4在内的细胞骨架蛋白的O-GlcNAcycy增加有关

Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4

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