Cellular CD4 T Cell Responses to the Diphtheria- Derived Carrier Protein of Conjugated Pneumococcal Vaccine and Antibody Responsen to Pneumococcal Vaccination in HIV-Infected Adults

摘要

Background. The French National Agency for AIDS and Viral Hepatitis Research (ANRS) 114 Pneumovac trial showed that a strategy combining a 7-valent pneumococcal conjugate vaccine (PCV) prime at week 0 followed by a 23-valent pneumococcal polysaccharide vaccine (PPV) boost at week 4 enhances the frequency and magnitude of immunoglobulin (Ig) G responses against Streptococcus pneumoniae polysaccharides (SPPs) compared with PPV alone. CD4 T cell responses specific to the diphtheria-derived carrier protein CRM₁₉₇ were evaluated.