Methylation of p16 gene in hematological malignancies

摘要

Conclusion The methylation of p16 gene plays an important role in the pathogenesis and the develop- ment of some hematological malignancies. The pa- tients with p16 gene methylation have poor prognosis. The detection of p16 gene is a useful tool for evaluation Prognosis of hematological malignancies. Objective To investigate the incidence of p16 Gene methylation in hematological malignancies, and The relations between p16 gene methylation and the Prognosis of hematological malignancies. Methods Fifty-five patients were studied by re- Striction nezyme polymerase chain reaction (PCR) to Detect p16 gene methylation.