Targeted diagnosis and treatment of superficial bladder cancer with monoclonal antibody BDI-1

摘要

Conclusion The bladder cancer seems an ideal model for diagnostic and therapeutic approaches using regional administration of McAb conjugates via a catheter direct into the bladder. Objective To explore the application of mono- clonal antibody (McAb) to targeted treatment of blad- der carcinoma through a series of in vitro and in vivo- studies carried out in animal model and patients with bladder carcinoma. Methods Monoclonal antibody BDI-1 against bladder carcinoma was prepared by the lymphocyte hy- bridoma technique. McAb was conjugated with ~99m Tc by direct reduction method.