首页> 外文期刊>Chinese Journal of Integrated Traditional and Western Medicine >Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure
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Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure

机译:生脉注射液对中度急性肾功能衰竭大鼠的保护作用

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Conclusion: SMI could prevent renal tis- sue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracel- lular calcium accumulation, inhibiting PLA_2 activity and dilating renal vessels. Objective: Radiogrpahic contrast media can induce renal failure and it may serve as an experi- Mental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawely (SD) rats. Methods: Twenty healthy SD rats of both sex were ranodmly divided into two groups, Group A (control group) treated with glycerin+0. 9/100 saline + megulcamine diatrizoate, and group B (preventive group) with glycerin+SMI+meglucamine dia- Trizoate.
机译:结论:SMI可以预防造影剂诱发的SD大鼠肾组织的肾脏病变。该作用可能部分归因于其阻止细胞内钙积累,抑制PLA_2活性和扩张肾血管。目的:放疗造影剂可诱发肾衰竭,并可作为急性肾衰竭(ARF)的实验模型。该研究旨在确定生脉注射液(SMI)对Sprague-Dawely(SD)大鼠与造影剂相关的ARF的保护作用。方法:将二十只健康的SD雌性大鼠随机分为两组,A组(对照组)用甘油+0处理。 9/100生理盐水+盐酸美古拉敏,B组(预防组)加甘油+ SMI +葡糖胺-三唑酸酯。

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