A MIXTURE OF CARBOXYLIC ACIDS, MORE SPECIFICALLY, CITRIC ACID, SUCCINIC ACID, FUMARIC ACID, MALIC ACID, AND THEIR USE FOR THE TREATMENT OF PATIENTS WITH CHRONIC RENAL FAILURE, ACUTE RENAL FAILURE, ACUTE OR CHRONIC HEPATOPATHIES ASSOCIATED WITH HYPERAMONEMIA, CONGENITAL DISEASES WITH ENZYMATIC ALTERATIONS IN THE UREA CYCLE, AS WELL AS CLINICAL CONDITIONS ASSOCIATED WITH A NEGATIVE NITROGEN BALANCE.

摘要

Currently, the treatment for patients with end-stage renal disease (stage V) consists in renal replacement therapy (hemodialysis, peritoneal dialysis or renal transplant), which is outstandingly expensive, thereby entailing a poor quality of life. The present invention discloses a mixture of carboxylic acids, citric acid, succinic acid, fumaric acid and malic acid, and any of the possible combinations thereof. Said product is preferably orally or intravenously administered in the therapy of patients with chronic renal failure, hyperamonemia or human conditions associated with a negative nitrogen balance. The product of the present invention is further beneficial for lowering the serum values of urea and serum ammonium, while by transamination of the oxalacelate formed via succinate and malate and fumarate, it promotes the biosynthesis of non- essential amino acids. Also, by transamination of the alpha-ketoglutarate formed via citrate, it generates glutamic acid and amino acids related therewith such as glutamine. This treatment is useful for preventing, preserving and improving renal function. In other patients it causes deterioration of renal function to be delayed, and the imperious need of a renal replacement therapy. In other patients, it is useful as a treatment complementary to the renal replacement therapy for improving the patient’s quality of life and the laboratory parameters.