Use of EP4 receptor selective agonists (5-(3-hydroxy-4-phenyl-but-1-enyl)-1-6-(1H-tetrazol-5-yl)-hexyl-pyrrolidin-2-one or 7-2-(3-hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-1-yl-heptanoic acid for the treatment of acute and chronic renal failure

摘要

An EP4 receptor selective agonist, an isomer thereof or a prodrug of the agonist or isomer or a pharmaceutically acceptable salt thereof is used to treat acute or chronic renal failure or dysfunction or a condition caused by acute or chronic renal failure or dysfunction. The EP4 receptor selective agonist can be 5-(3-hydroxy-4-phenyl-but-1-enyl)-1-[6-(1H-tetrazol-5-yl)-hexyl]-pyrrolidin-2-one, 5-(3-hydroxy-4-phenyl-butyl)-1-[6-(1H-tetrazol-5-yl)-hexyl]-pyrrolidin-2-one, 7-(2-(3-hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-1-yl)-heptanoic acid or 7-[2-(3-hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid.