Asymmetric Direct Aldol Reaction of Cyclohexanone Catalyzed by (N′-Benzyl-N′-D-prolyl)-trans-4-hydroxy-L-proline Hydrazide

摘要

A new proline catalyst, namely (N′-benzyl-N′-D-prolyl)-trans-4-hydroxy-L-proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98:2 dr and 98% ee.