Asymmetric Direct Aldol Reaction of Cyclohexanone Catalyzed by( N'-Benzyl-N'-D-prolyl)-trans-4-hydroxy-L-proline Hydrazide

摘要

A new proline catalyst,namely(N'-benzyl-N'-D-prolyl)-trans-4-hydroxy-L-proline hydrazide,has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes,affording up to 98:2dr and 98% ee.