A Novel Approach to Assess the Bioactive and Cytotoxic Potential of Novel Biomaterials: The Agar Diffusion Scratch Assay

摘要

Many physiological processes, such as tissue repair and regeneration, as well as immune system responses rely on cell migration. In vitro, cell migration can be affected by numerous different alterations in cell physiology, e.g. gene expression, signalling, and/or a modified interaction with the extracellular matrix. Therefore, using cell migration as a bioactivity indicator allows cell performance to be evaluated in a quantitative, qualitative, and time-dependent manner.