Inside Cover: Metal-Binding Properties of an Hpn-Like Histidine-Rich Protein (Chem. Eur. J. 21/2011)

摘要

Hpnl protein, an important histidine- and glutamine-rich protein for Helicobacter pylori colonization in human gastric muscosa, binds divalent metal ions and plays essential roles in the bacterial detoxification. In their Full Paper on page 5852 ff., H. Sun et al. show that only nickel confers a higher stability on Hpnl than other metal ions, and that His29 and His31 are crucial for nickel binding.