How to very efficiently functionalize gold nanoparticles by 'click' chemistry

摘要

Difficulties previously encountered in the very useful "click" functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1 : 1 water-THF medium, stoichiometric CUSO_4 and sodium ascor-bate, inert atmosphere at 20 ℃ that provide quantitative "click" reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.rnFunctionalization of gold nanoparticles (AuNPs) is a key challenge given the broad range of applications of AuNPs in biology, nanomedicine, optics and catalysis. Since the seminal reports by Brust and Schiffrin6 of the stable alkylthiolate AuNPs, considerable interest has arisen in their chemistry and physics. A large variety of functional AuNPs are now known, but many families of AuNPs are still resistant to direct synthesis, ligand exchange reactions or functionalization using high-temperature or other incompatible processes.