A potential role for protein tyrosine phosphatase inhibition by a Ru ~(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity

摘要

Ruthenium complexes containing polyaminocarboxylate (pac) ligands are promising with regard to potential biological applications, including their potential as chemotherapeutic agents. For example, they show good antitumor activities, inhibit DNA recognition and DNA lysis, and stimulate NADPH oxidase and a respiratory burst in phagocytic neu-trophils. This arises through the binding of bio-molecules via rapid and facile aqua-substitution reactions and a range of accessible oxidation states. They also possess catalytic properties that mimic the enzymatic hydrocarbon oxidations catalysed by cytochrome P-450 under homogeneous conditions.