A fast synthetic route to GDP-sugars modified at the nucleobase

摘要

The direct structural modification of GDP-mannose via the bromination and Suzuki-Miyaura cross-coupling of the unprotected sugar-nucleotide, to produce 8-substituted fluorescent analogues of GDP-mannose. GDP (guanosine diphosphate)-mannose (Fig. 1) is a natural substrate for many biologically important and therapeutically relevant glycoprocessing enzymes.