One-pot cascade Michael-Michael-Aldol condensation for diastereoselective synthesis of nitro-substituted cyclohexanes

摘要

A one-pot reaction of nitroalkenes and enones was developed for the preparation of nitro-vinyl-substituted cyclohexanes, which could be simply converted into poly-N-heterocycles.rnCascade processes have a long tradition as efficient approaches in complex molecule synthesis. Compared to the Lewis acid-, radical- and transition metal-promoted cascade reactions, Lewis base (LB)-mediated cascade transformations are much less studied.