Evidence Of Strong Hydrogen Bonding By 8-aminoguanine

摘要

DNA oligonucleotides containing 8-aminodeoxyguanosine residues form a pH-dependent self-structure with strong hydrogen bonds.rnOf the molecular recognition tools available to supramolecular chemists, hydrogen bond complementarity is arguably the most often-used and conceptually easiest to appreciate. Rationally-designed assemblies that use hydrogen bond complementarity are sometimes described as "DNA mimics" or "DNA-like," in reference to the selective hydrogen bonding of Watson-Crick base pairs. Here, we propose that a subclass of hydrogen bonds could further expand the supramolecular toolbox. Using a model system of oligonucleotides with modified guanine residues, we demonstrate the ability of strong hydrogen bonds to drive duplex formation with non-Watson-Crick base pairs.