Stereoselective synthesis of trans-β-lactams by palladium-catalysed carbonylation of vinyl aziridines

摘要

The palladium-catalysed carbonylation of vinyl aziridines can give either the trans- or cis-β-lactam preferentially or even the δ-lactam simply by adjusting the reaction parameters ([Pd], [CO], temperature).β-Lactams have a long and illustrious history in the field of medicinal chemistry. As such, methods for their construction with stereocontrol have been, and still are, highly important to the continued development of the area.