SYNTHESIS OF HIGHLY STEREOSELECTIVE BETA-LACTAM DERIVATIVE

摘要

PURPOSE: To efficiently obtain the derivative useful for thienamycin in a high yield by reacting an organic ester lithium enolate with a specific organic imine compound in THF. ;CONSTITUTION: The lithium enolate of an organic ester such as β-hydroxybutyric acid ethyl ester is reacted with an organic imine compound such as an imine coordinated with a trialkylaluminum in THF to obtain this derivative.;COPYRIGHT: (C)1994,JPO&Japio