Molecular sensitivity of DNA-Ag-PATP hybrid on optical activity for ultratrace mercury analysis

摘要

The para-aminothiophenol (PATP), in which the thiol groups adsorbed on the Ag surface and the amino groups coordinated with Hg~(2+), can mediate the aggregation of sunlight-reduced λ-DNA-templated Ag nanoparticles, resulting in high molecular sensitivity of this hybrid on optical activity. Sub-pM levels of Hg~(2+) assays were achieved based on this molecular stepwise assembly. Monolayer, multilayer or chiral supramolecular stepwise assembly offers an attractive, versatile method to design and construct intrinsically acentric materials with excellent electro-optical properties.1 In particular, DNA as a template to build new materials from metal nanoparticles (NPs) greatly expands the field of molecular diagnostics for the detection of nucleic acids, proteins, gases, metal ions, and more.