A new route for the synthesis of polyhedral gold mesocages and shape effect in single-particle surface-enhanced Raman spectroscopy

摘要

We have demonstrated a new strategy to synthesize Au mesocages using polyhedral Cu_2O templates. The obtained polyhedral Au mesocages show a strong shape effect in highly sensitive single-particle surface-enhanced Raman spectroscopy (sp-SERS). SERS-based signal detection and molecular identification is a powerful chemical sensing method with numerous potential applications in biomedicine, life science, analytical chemistry, etc,~1 "Hot spots" where a local Raman enhancement is as high as～10~(10) or more have been observed for a number of substrates and nanoparticle aggregates by using Raman microscopy techniques.1* However, the lack of reproducibility and reliability with high sensitivity still hampers practical applications of SERS molecule detection.