Exploring the effect of sialic acid orientation on ligand-receptor interactions

摘要

Here, we present the synthesis of two sialo-micelles to validate the significance of sialic acid orientation during specific carbohydrate-protein and carbohydrate-carbohydrate interactions. Our data clearly suggest that orientation of carboxylic acid and glycerol side chains of sialic acid moieties exert fine tuning of ligand-receptor interactions.