首页> 外文期刊>Chemical Communications >Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(Ⅱ) drugs
【24h】

Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(Ⅱ) drugs

机译:通过静电相互作用形成胶束纳米颗粒,以递送多核铂(Ⅱ)药物

获取原文
获取原文并翻译 | 示例
           

摘要

Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(Ⅱ) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.
机译:通过甲氧基-聚乙二醇嵌段-聚谷氨酸(MPEG-PGA)与多核铂(Ⅱ)药物di-cisPt之间的静电相互作用形成的纳米颗粒,具有有效的铂负载量,改善的细胞摄取,体外细胞毒性和增强体内功效。

著录项

  • 来源
    《Chemical Communications》 |2013年第42期|4809-4811|共3页
  • 作者单位

    Department of Chemical and Biomolecular Engineering, University of Notre Dame Notre Dame, IN 46556, USA;

    Department of Chemical and Biomolecular Engineering, University of Notre Dame Notre Dame, IN 46556, USA;

    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, PR China;

    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China;

    Department of Chemical and Biomolecular Engineering, University of Notre Dame Notre Dame, IN 46556, USA,Advanced Diagnostics and Therpeutics, University of Notre Dame, Notre Dame, IN USA;

    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, PR China;

    Department of Chemical and Biomolecular Engineering, University of Notre Dame Notre Dame, IN 46556, USA,Advanced Diagnostics and Therpeutics, University of Notre Dame, Notre Dame, IN USA ,Mike and Josie Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号