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Design of tetraplex specific ligands: cyclic naphthalene diimide

机译：四重体特定配体的设计：环萘二酰亚胺

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摘要

Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5'-AGGG(TTAGGG)_3-3' (K = 8.6 × 10~6 M~(-1)) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5'-GGG AGG TTT CGC-3' and 3'-CCC TCC AAA GCG-5' (nK = 3.3 × 10~4 M~(-1)) with 0.5 μM of IC_(50) for telomerase activity.
机译：环状萘二酰亚胺1与5'-AGGG（TTAGGG）_3-3'（K = 8.6×10〜6 M〜（-1））的杂合型四链体DNA结合的亲和力比与双链结合的结合力大260倍由5'-GGG AGG TTT CGC-3'和3'-CCC TCC AAA GCG-5'（nK = 3.3×10〜4 M〜（-1））和0.5μMIC_（50）的端粒酶活性组成的寡核苷酸。

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  • 来源
    《Chemical Communications》 |2014年第45期|5967-5969|共3页
  • 作者

    Yugo Esaki; Monirul Islam; Satoshi Fujii; Shinobu Sato; Shigeori Takenaka;

  • 作者单位

    Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan;

    Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan;

    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka 820-8502, Japan;

    Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan,Research Center for Bio-microsensing Technology, Kyushu Institute of Technology, Fukuoka 804-8550, Japan;

    Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan,Research Center for Bio-microsensing Technology, Kyushu Institute of Technology, Fukuoka 804-8550, Japan;

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  • 入库时间 2022-08-17 13:15:50

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