Self-complementary purines by quadruple hydrogen bonding

摘要

The first discrete,self-complementary,quadruply hydrogen-bonded complexes based on the 2,6-diaminopurine (DAP)scaffold have been prepared;regioselective urea formation at the C(2)amino group of the heterocycle allows intermolecular dimerization (K_(dim)approx 1-1.6 x 10~3 M~(-1)in CDCl_3)through a DADA hydrogen bonding motif.