Intramolecular Stetter cyclisation of Morita-Baylis-Hillman adducts: a versatile approach towards bicycloenediones

摘要

Bicyclic enediones of various sizes can be efficiently assembled by intramolecular Stetter cyclisation of readily available Morita-Baylis-Hillman adducts. Bicyclic structures are ubiquitous subunits in a wide variety of natural products such as coronatine and guaiol (Fig. 1). The occurrence of these substructures has stimulated the development of numerous and elegant procedures for their efficient construction.