Intramolecular Morita-Baylis-Hillman Reaction Using Chiral Phosphine Catalysts and the Synthetic Application

摘要

Recently, we found that newly developed chiral phosphine catalysts possessing a highly acidic sulfonamide due to the electron deficient substituents was quite effective for the acceleration of enantioselective intramolecular Morita-Baylis-Hillman reaction of an enone 1 to form a bicyclic molecule 2 such as C, D ring of steroid compounds.