Up-regulated Endogenous Erythropoietin/Erythropoietin Receptor System and Exogenous Erythropoietin Rescue Retinal Ganglion Cells after Chronic Ocular Hypertension

Qing-Ling Fu; Wutian Wu; Hua Wang; Xin Li; Vincent W. H. Lee; Kwok-Fai So

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Up-regulated Endogenous Erythropoietin/Erythropoietin Receptor System and Exogenous Erythropoietin Rescue Retinal Ganglion Cells after Chronic Ocular Hypertension

机译：慢性高眼压后内源性促红细胞生成素/促红细胞生成素受体系统和外源性促红细胞生成素拯救视网膜神经节细胞上调

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Aims Recent studies have showed that erythropoietin (EPO) is a neuroprotectant for central nerve system neurons in addition to being a hematopoietic cytokine in response to hypoxia. In this study, we investigate the role of the EPO/EPO receptor (EPOR) system in the rat retina after ocular hypertension injury that mimics glaucoma.

机译：目的近期研究表明，促红细胞生成素（EPO）除了是对缺氧的造血细胞因子外，还对中枢神经系统神经元具有神经保护作用。在这项研究中，我们调查了模仿青光眼的高眼压损伤后大鼠视网膜中EPO / EPO受体（EPOR）系统的作用。

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《Cellular and Molecular Neurobiology》 |2008年第2期|p.317-329|共13页
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Qing-Ling Fu; Wutian Wu; Hua Wang; Xin Li; Vincent W. H. Lee; Kwok-Fai So;
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1. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. [J] . Fu QL, Wu W, Wang H, Cellular and Molecular Neurobiology . 2008,第2期

机译：慢性高眼压后，上调内源性促红细胞生成素/促红细胞生成素受体系统和外源性促红细胞生成素可拯救视网膜神经节细胞。
2. P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model [J] . Dong Lingdan, Hu Yanhong, Zhou Long, Molecular medicine reports . 2018,第2aPta1期

机译：P2X7受体拮抗剂通过抑制大鼠慢性眼高血压模型中的微胶质激活来保护视网膜神经节细胞
3. Group II metabotropic glutamate receptor agonist promotes retinal ganglion cell survival by reducing neuronal excitotoxicity in a rat chronic ocular hypertension model [J] . Neuropharmacology . 2020,第期

机译：II组代谢谷氨酸受体激动剂通过减少大鼠慢性眼高血压模型中的神经元速度毒性来促进视网膜神经节细胞存活
4. Characterization of the Erythropoietin (EPO) Protein Production in the Recombinant Human Cultured Cells, in which the Exogenous EPO Gene was Introduced into Hypoxanthine Phosphoribosyl Transferase (HP [C] . Toshiaki Banzai, Yukiko Koyama, Shuji Sonezaki Annual and International Meeting of the Japanese Association for Animal Cell Technology . 2010

机译：重组人类培养细胞中促红细胞生成素（EPO）蛋白质产生的表征，其中将外源EPO基因引入缺氧磷酰基转移酶（HP
5. Synthesis of Neo-Glycosylated Human Erythropoietin and Investigation Into Interaction With the Erythropoietin Receptor [D] . Richardson, Dominique. 2014

机译：新糖基化人促红细胞生成素的合成及其与促红细胞生成素受体相互作用的研究
6. Neuroprotective effects of exogenous erythropoietin in Wistar rats by downregulating apoptotic factors to attenuate N-methyl-D-aspartate-mediated retinal ganglion cells death [O] . Wen-Sheng Cheng, I-Hung Lin, Kathy Ming Feng, 2020

机译：下调凋亡因子衰减N-甲基-D-天冬氨酸介导的视网膜神经神经节细胞死亡中外源性促红细胞生成素对Wistar大鼠的神经保护作用
7. Neuroprotective effects of exogenous erythropoietin in Wistar rats by downregulating apoptotic factors to attenuate N-methyl-D-aspartate-mediated retinal ganglion cells death [O] . Wen-Sheng Cheng, I-Hung Lin, Kathy Ming Feng, 2020

机译：下调凋亡因子衰减N-甲基-D-天冬氨酸介导的视网膜神经神经节细胞死亡中外源性促红细胞生成素对Wistar大鼠的神经保护作用

Up-regulated Endogenous Erythropoietin/Erythropoietin Receptor System and Exogenous Erythropoietin Rescue Retinal Ganglion Cells after Chronic Ocular Hypertension

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