Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats

Diane Goltz; Jobst-Hendrik Schultz; Carolin Stucke; Michael Wagner; Peter Bassalaý; Alexander Peter Schwoerer; Heimo Ehmke; and Tilmann Volk

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Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats

机译：Kv4.2 / 3降低但不降低KChIP2水平降低自发性高血压大鼠的心脏瞬时向外K + 电流

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Objective: A reduction of the Ca2+-independent transient outward potassium current (I_to) in epicardial but not in endocardial myocytes of the left ventricle has been observed in cardiac hypertrophy and is thought to contribute to the electrical vulnerability associated with this pathology.

机译：目的：在心脏肥大中，观察到左心室心外膜而非心内膜心肌中Ca 2 + 依赖性的瞬时外向钾电流（I _{to ）的减少并且被认为会导致与此病理相关的电气脆弱性。}

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《Cardiovascular Research》 |2007年第1期|85-95|共11页
作者
Diane Goltz; Jobst-Hendrik Schultz; Carolin Stucke; Michael Wagner; Peter Bassalaý; Alexander Peter Schwoerer; Heimo Ehmke; and Tilmann Volk;
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Institut für Vegetative Physiologie und Pathophysiologie Universitätsklinikum Hamburg-Eppendorf Martinistraβe 52 20246 Hamburg Germany;

Institut für Zelluläre und Molekulare Physiologie Friedrich-Alexander-Universität Erlangen-Nürnberg Waldstraβe 6 91054 Erlangen Germany;

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1. Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytes [J] . Rudakova Elena, Wagner Michael, Frank Magdalena, Pfluegers Archiv: European Journal of Physiology . 2015,第2期

机译：脂质筏中Kv4.2和KChIP2的定位以及大鼠左心室心肌细胞膜胆固醇含量对向外K +电流的调节
2. Stabilization of Kv4 protein by the accessory K+ channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K+ currents [J] . FoegerN.C., WangW., MellorR.L., The Journal of Physiology . 2013,第17期

机译：通过辅助K +通道相互作用蛋白2（KChIP2）亚基稳定Kv4蛋白是产生天然心肌快速瞬态向外K +电流所必需的
3. Prolonged leptin treatment increases transient outward K+ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes [J] . Gómez-HurtadoN., Fernández-VelascoM., Fernández-AlfonsoM.S., Pfluegers Archiv: European Journal of Physiology . 2014,第5期

机译：瘦素的长期治疗通过成年大鼠心室肌细胞中Kv4.2和Kv4.3通道亚基的上调来增加瞬时向外K +电流
4. Development of transient outward K/sup +/ current to simulate ventricular action potentials of spontaneously hypertensive rats [C] . Padmala, S., Giles, . 2002

机译：瞬态向外K / sup + /电流的发展以模拟自发性高血压大鼠的心室动作电位
5. CARBOHYDRATE AND LIPID METABOLISM IN OBESE SPONTANEOUSLY HYPERTENSIVE RATS FED TWO LEVELS OF CARBOHYDRATE [D] . FERRUGGIARO, EILEEN BONNER 1982

机译：两种水平的自发性高血压大鼠的碳水化合物和脂质代谢
6. Stabilization of Kv4 protein by the accessory K+ channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K+ currents [O] . Nicholas C Foeger, Wei Wang, Rebecca L Mellor, 2013

机译：通过辅助K +通道相互作用蛋白2（KChIP2）亚基稳定Kv4蛋白是产生天然心肌快速瞬态向外K +电流所必需的
7. Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats [O] . D GOLTZ, J SCHULTZ, C STUCKE, 2007

机译：减少kV4.2 / 3但不是Kchip2水平降低了自发性高血压大鼠中的心脏瞬态向外K +电流

Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats

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