Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection

摘要

Objective: Regional differences in repolarizing K+ current densities and expression levels of their molecular components are important for coordinating the pattern of electrical excitation and repolarization of the heart. The small size of hearts from mice may obscure these interventricular and/or transmural expression differences of K+ channels. We have examined this possibility in adult mouse ventricle using a technology that provides very high spatial resolution of tissue collection.