Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients

Hui Wang; Chuanping Cao; Beilei Li; Shaoliang Chen; Jun Yin; Jing Shi; Dan Ye; Qun Tao; Peisheng Hu; Alan Epstein; Dianwen Ju

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Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients

机译：碘131嵌合肿瘤坏死治疗单克隆抗体对晚期肺癌的免疫原性

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摘要

Iodine-131 radiolabeled chimeric tumor necrosis therapy monoclonal antibody (131I-TNT) has been approved for the treatment of advanced lung cancer in China. In the present study, the immunogenicity of TNT was studied in advanced lung cancer patients using BIACORE and enzyme linked immunosorbent assay (ELISA) methods.

机译：碘131放射性标记的嵌合肿瘤坏死治疗单克隆抗体（131 I-TNT）已在中国被批准用于治疗晚期肺癌。在本研究中，使用BIACORE和酶联免疫吸附测定（ELISA）方法研究了晚期肺癌患者TNT的免疫原性。

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来源
《Cancer Immunology, Immunotherapy 》 |2008年第5期| 677-684| 共8页
作者
Hui Wang; Chuanping Cao; Beilei Li; Shaoliang Chen; Jun Yin; Jing Shi; Dan Ye; Qun Tao; Peisheng Hu; Alan Epstein; Dianwen Ju;
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作者单位

Institute of Microbiology and Epidemiology Academy of Military Medical Science Beijing 100071 China;

Shanghai MediPharm Biotech Co. Ltd 865 Zu Chong Zhi Road Shanghai 201203 China;

Department of Nuclear Medicine Zhongshan Hospital Fudan University Shanghai China;

Department of Nuclear Medicine Zhongshan Hospital Fudan University Shanghai China;

Institute of Microbiology and Epidemiology Academy of Military Medical Science Beijing 100071 China;

Institute of Microbiology and Epidemiology Academy of Military Medical Science Beijing 100071 China;

Shanghai MediPharm Biotech Co. Ltd 865 Zu Chong Zhi Road Shanghai 201203 China;

Shanghai MediPharm Biotech Co. Ltd 865 Zu Chong Zhi Road Shanghai 201203 China;

Department of Pathology University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

Department of Pathology University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

Shanghai MediPharm Biotech Co. Ltd 865 Zu Chong Zhi Road Shanghai 201203 China;

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专利

1. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. [J] . Chen S, Yu L, Jiang C, Journal of Clinical Oncology . 2005 ,第7期

机译：碘131标记的嵌合肿瘤坏死治疗放射免疫疗法对晚期肺癌患者的重要研究。
2. Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. [J] . Reardon DA, Akabani G, Coleman RE, Journal of Clinical Oncology . 2006 ,第1期

机译：小鼠碘131标记的抗腱糖蛋白单克隆抗体81C6挽救性放射免疫疗法治疗复发性原发和转移性恶性脑肿瘤的患者：II期研究结果。
3. Phase II trial of mapatumumab, a fully human agonist monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer [J] . VonPawelJ., HarveyJ.H., SpigelD.R., Clinical lung cancer . 2014 ,第3期

机译：Mapatumumab（一种针对肿瘤坏死因子相关的凋亡诱导配体受体1（TRAIL-R1）的全人类激动剂单克隆抗体）与紫杉醇和卡铂联合用于晚期非小细胞肺癌患者的II期临床试验
4. Iodine-131 Labeled Monoclonal Antibody in The Diagnosis of Colon Cancer [C] . Y.Ng, S.Mohd, W.H.B.W.Kamal, Trends in Radiopharmaceuticals(ISTR-2005) . 2007

机译：碘131标记的单克隆抗体在结肠癌的诊断中
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Tumor necrosis factor-related apoptosis-inducing ligand additive with Iodine-131 of inhibits non-small cell lung cancer cells through promoting apoptosis [O] . Ning Yang, Shuzhan Yao, Dong Liu -1

机译：碘131与肿瘤坏死因子相关的凋亡诱导配体添加剂通过促进细胞凋亡抑制非小细胞肺癌细胞
7. In vitro and in vivo targeting properties of iodine-123- or iodine-131-labeled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model. [O] . Burvenich, I, Schoonooghe, S, Cornelissen, B, 2005

机译：碘-123-或碘-131标记的单克隆抗体14C5在非小细胞肺癌和结肠癌模型中的体外和体内靶向特性。

Immunogenicity of Iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients

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