Hyperhomocysteinemia and Cardiovascular Diseases in Algeria People

摘要

Epidemiological research has shown that elevated total homocysteine (they) is a risk factor for atherosclerosis disease. This study was carried in symptomatic patients with cardiovascular disease n= 63 and asymptomatic n= 27. There was a significant decrease in Total-cholesterol (3.65mmol/l ±1.25) and HDL-cholesterol (0.84mmol/l±0.48) in symptomatic patients and compared with asymptomatic the concentration of Total-cholesterol was (4.12mmol/l±0.84) and HDL-cholesterol was (1.17mmol/l ±0.54). The concentration of enzymes LDH, CK and ALP (271.47units/l±/29.18, 121.34units/l ± 142.50 and 232.57units/l±95.72), respectively in symptomatic patient and in asymptomatic control group were (170units/l±46.3, 74.3units/l±38.50 and 132.73units/l±59.81), respectively, these values are increased significantly between two groups. The main values of thiols (homocysteine; cysteinylglycine, glutathione oxidized and reduced) were higher in patients with cardiovasculardisease (10.21 μmol/l±5.59, 32.38μmol/l±22.34, 17.91μmol/l±8.83 and 32.96μmol/l±17.34), respectively than in asymptomatic subjects where the concentration of thiols were (7.67μmol/l±2.66, 25.48μmol/l±11.11,6.66μmol/l±2.79 and 12.0μmol/l±5.18).rnThe main value of homocysteine (12.89μmol/l±4.59) was increased highly and significantly in symptomatic postmenopausal women in contrast to homocysteine concentration (8.45μmol/l±4.94) in male patients.rnOur study suggests that plasma level total homocysteine is an independent risk factor in atherogenic process.