Inclusion Complexes Of Meloxicam And Cyclodextrins

摘要

The interaction of meloxicam with cyclodextrins was investigated. The formation of a 1:1 inclusion complex with hydroxy propyl β-cyclodextrin and a 1:2 complex with β-cyclodextrin was established. Characterization was conducted by FTIR spectroscopy, XRD, TGA and ~1H-NMR spectroscopy studies. The solubility increased by increasing pH from 1.2 -6.8. The dissolution rates revealed enhanced dissolution properties of the cyclodextrin complexes compared to the drug. The partition between n-octanol and 0.1 N HCl or Mclvaine's citric acid phosphate buffer, revealed that the partition coefficient of meloxicam is higher compared to complexes with cyclodextrins. The present study denotes the capability of forming a more soluble product of meloxicam, at physiologic pH, via complexation with cyclodextrins which would result in enhanced bioavailability and improved efficacy.