Inhibitory effects of EGFR antisense oligodeox- ynucleotide in human colorectal cancer cell line

摘要

Epidermal-growth-factor receptor~[1] (EGFR) is a polypeptide with 1186 amino acids, which binds to EGF family growth factors. Two major natural Ligands in the family interact with EGFR: one is EGF, the other is transforming growth factor-α (TGF-α)~[2]. When EGF or TGF-α, binds to EGFR, tyrosine kinase activity is induced which in turn triggers a series of events regulating the cell growth~[3-8]. The importance of EGFR in growth regulating pathways was confirmed by the fact that enhanced expression of this receptor was found in brain gliobastomas, breast, lung, ovarian, colorectal, and renal carcinomas.