Role of P-selectin and anti-P-selectin monoclonal antibody in apoptosis during hepatic/renal ischemia-reperfusion injury

摘要

AIM To evaluale the potential role of P-selectin and anti-P-selectin monoclonal antibody (mAb) in apoptosis during hepatic/renal ischemia- reperfusion injury. METHODS Plasma P-selectin level, hepatic/ Renal P-selectin expression and cell apoptosis Were detected in rat model of hepatic/ renal Ischemia-reperfusion injury. ELISA, immunohist- Ochemistry and TUNEL were used. Some Ischemic-reperfusion rats were treated with anti- P-selectin mAb.