Research in osteogenesis imperfecta (the brittle bone syndrome) has contributed exciting new chapters in bone biology, but little advance in treatment (International Conference on Osteogenesis Imperfecta, Montreal 1999). Specialised rehabilitation and timely appropriate surgery remain the therapeutic cornerstones. Calcitonin (to reduce bone resorption) and sodium fluoride (to increase formation) are ineffective. Two new approaches using the aminobis-phosphonates and stromal cell transplantation now deserve our critical attention.
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