Drug points: Ticlopidine associated with acute arthritis

摘要

Ticlopidine is an antiplatelet thienopyridine drug that works by non-competitive antagonism of the ADP receptor. It is used widely to prevent thrombosis after coronary stent placement and has been shown to be at least as effective as aspirin in preventing events in patients with cerebrovascular disease. Its most common side effects include diarrhoea, nausea, vomiting, and skin rash. It also has serious-but rare-side effects such as neulropenia, thrombotic thrombocytopenic purpura, and bone marrow aplasia. We report a case of acute arthritis associated with ticlopidine.