Simulation of the Phase-I Metabolism of the Antiplatelet Drug Ticlopidine with Electrochemistry/Liquid Chromatography/Mass Spectrometry

摘要

Ticlopidine forms various products during electrochemical oxidation. Main products are: m/z 262: Dihydrothienopyridinium product M1. m/z 260: Thienopyridinium product M2. M1, M2 were also found in microsomal incubations (Dalvie and O' Connel, 2004).